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research article

A low-power high-sensitivity single-chip receiver for NMR microscopy

Anders, Jens
•
Handwerker, Jonas
•
Ortmanns, Maurits
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2016
Journal of Magnetic Resonance

In this paper, we present a fully-integrated receiver for NMR microscopy applications manufactured in a 0.13 mu m CMOS technology. The design co-integrates a 10-turn planar detection coil together with a complete quadrature, low-IF downconversion receiver on a single chip, which operates from a single 1.5 V supply with a total power dissipation of 18 mW. The detector's measured time-domain spin sensitivity is 3 x 10(13) H-1 spins/root Hz at 7 T. Additionally, the paper discusses two important aspects of NMR microscopy using planar detection coils: the link between the detection coil's spin sensitivity and the achievable image SNR and the correction of image artifacts induced by the inhomogeneous sensitivity profile of planar detection coils. More specifically, we derive analytical expressions for both the theoretical image SNR as a function of the coil's spin sensitivity and the sensitivity correction for a known coil sensitivity profile in CTI MR imaging experiments. Both expressions are validated using measured data in the imaging section of the paper. Thanks to the improved spin sensitivity of the utilized integrated receiver chip compared to a previously presented design, we were able to obtain sensitivity corrected images in a 7 T spectroscopy magnet with isotropic resolutions of 9.6 mu m and 5 mu m with single-shot SNRs of 37 and 15 in relatively short imaging times of 4.4 h and 24 h, respectively. (C) 2016 Elsevier Inc. All rights reserved.

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Type
research article
DOI
10.1016/j.jmr.2016.03.004
Web of Science ID

WOS:000375510100005

Author(s)
Anders, Jens
Handwerker, Jonas
Ortmanns, Maurits
Boero, Giovanni  
Date Issued

2016

Publisher

Academic Press Inc - Elsevier Science

Published in
Journal of Magnetic Resonance
Volume

266

Start page

41

End page

50

Subjects

MRI

•

Micro-MRI

•

NMR microscopy

•

Integrated circuits

•

CMOS

•

Planar microcoils

•

Sensitivity correction

•

Signal-to-noise ratio

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LMIS1  
Available on Infoscience
July 19, 2016
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/127792
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