A Functional Model of [Fe]-Hydrogenase

[Fe]-Hydrogenase catalyzes the hydrogenation of a biological substrate via the heterolytic splitting of molecular hydrogen. While many synthetic models of [Fe]-hydrogenase have been prepared, none yet are capable of activating H-2 on their own. Here, we report the first Fe-based functional mimic of the active site of [Fe]-hydrogenase, which was developed based on a mechanistic understanding. The activity of this iron model complex is enabled by its unique ligand environment, consisting of biomimetic pyridinylacyl and carbonyl ligands, as well as a bioinspired diphosphine ligand with a pendant amine moiety. The model complex activates H-2 and mediates hydrogenation of an aldehyde.


Published in:
Journal Of The American Chemical Society, 138, 10, 3270-3273
Year:
2016
Publisher:
Washington, American Chemical Society
ISSN:
0002-7863
Laboratories:




 Record created 2016-07-19, last modified 2018-03-17


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