Loading...
research article
2-(Trifluoromethyl)indoles via Pd(0)-Catalyzed C(sp(3))-H Functionalization of Trifluoroacetimidoyl Chlorides
2016
Perfluoroalkylated indoles are valuable compounds in drug discovery. A Pd(0)-catalyzed C(sp(3))-H functionalization enables access to 2-(trifluoromethyl)indoles from trifluoroacetimidoyl chlorides. These are stable compounds, easily obtained from anilines. The cyclization operates with catalyst loadings as low as 1 mol % and accommodates a variety of substituents.
Type
research article
Web of Science ID
WOS:000374436800056
Authors
Publication date
2016
Publisher
Published in
Volume
18
Issue
8
Start page
1932
End page
1935
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
July 19, 2016
Use this identifier to reference this record