2-(Trifluoromethyl)indoles via Pd(0)-Catalyzed C(sp(3))-H Functionalization of Trifluoroacetimidoyl Chlorides

Perfluoroalkylated indoles are valuable compounds in drug discovery. A Pd(0)-catalyzed C(sp(3))-H functionalization enables access to 2-(trifluoromethyl)indoles from trifluoroacetimidoyl chlorides. These are stable compounds, easily obtained from anilines. The cyclization operates with catalyst loadings as low as 1 mol % and accommodates a variety of substituents.


Published in:
Organic Letters, 18, 8, 1932-1935
Year:
2016
Publisher:
Washington, American Chemical Society
ISSN:
1523-7060
Laboratories:




 Record created 2016-07-19, last modified 2018-09-13


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