Spontaneous Vesicle Self-Assembly: A Mesoscopic View of Membrane Dynamics

Amphiphilic vesicles are ubiquitous in living cells and industrially interesting as drug delivery vehicles. Vesicle self-assembly proceeds rapidly from nanometer to micrometer length scales and is too fast to image experimentally but too slow for molecular dynamics simulations. Here, we use parallel dissipative particle dynamics (DPD) to follow spontaneous vesicle self-assembly for up to 445 μs with near-molecular resolution. The mean mass and radius of gyration of growing amphi- philic clusters obey power laws with exponents of 0.85 ( 0.03 and 0.41 ( 0.02, respectively. We show that DPD provides a computational window onto fluid dynam- ics on scales unreachable by other explicit-solvent simulations.


Published in:
Langmuir, 28, 1, 541-547
Year:
2012
Publisher:
American Chemical Society
ISSN:
1520-5827
Keywords:
Laboratories:




 Record created 2016-07-07, last modified 2018-03-17


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