Integration of nanowire structures in more complex platforms combining microfluidics and multiplexing aspects may complex the electrical readout process. In the present work, fabrication of Aluminium (Al) lines for electrical connections is attempted followed by their integration to nanofabricated Memristive Biosensors that target at the label- free detection of cancer biomarkers. In addition a computational study is carried out investigating the impact of the resistance introduced by the additional Al connections to the electrical response of the Memristive Biosensors. Overall, the present study explores the restrictions and the possibilities of the Memristive Biosensors’ integration with additional elements that would allow effective readout in more complex configurations.