While both fundamental limits and system implementations are well understood for the point-to-point communication system, much less is developed for general communication networks. This thesis contributes towards the design and analysis of advanced coding schemes for multi-user communication networks with structured codes. The first part of the thesis investigates the usefulness of lattice codes in Gaussian networks with a generalized compute-and-forward scheme. As an application, we introduce a novel multiple access technique --- Compute-Forward Multiple Access (CFMA), and show that it achieves the capacity region of the Gaussian multiple access channel (MAC) with low receiver complexities. Similar coding schemes are also devised for other multi-user networks, including the Gaussian MAC with states, the two-way relay channel, the many-to-one interference channel, etc., demonstrating improvements of system performance because of the good interference mitigation property of lattice codes. As a common theme in the thesis, computing the sum of codewords over a Gaussian MAC is of particular theoretical importance. We study this problem with nested linear codes, and improve upon the currently best known results obtained by nested lattice codes. Inspired by the advantages of linear and lattice codes in Gaussian networks, we make a further step towards understanding intrinsic properties of the sum of linear codes. The final part of the thesis introduces the notion of typical sumset and presents asymptotic results on the typical sumset size of linear codes. The results offer new insight to coding schemes with structured codes.