A new feed-forward control technique for a DC-DC step-up converter based on the asymmet-ric Multistage Stacked Boost Architecture (MSBA) is presented in this paper. The proposed closed loop control scheme can provide improved accuracy in the steady-state operation and high dynamic performance. The asymmetric MSBA converter is a single output high-voltage DC-DC step-up converter that comprises several in-series connected capacitors with active voltage balancing circuits. The converter can attain high voltage ratios and thus, it is a suita-ble solution for the high voltage transmission requirements of the large photovoltaic (PV) plants. Selective simulation and experimental results are presented in order to validate the effectiveness and the operational improvements of the proposed control system.