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research article

Infrared Plasmonic Biosensor for Real-Time and Label-Free Monitoring of Lipid Membranes

Limaj, Odeta
•
Etezadi, Dordaneh  
•
Wittenberg, Nathan J.
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2016
Nano Letters

In this work, we present an infrared plasmonic biosensor for chemical-specific detection and monitoring of biomimetic lipid membranes in a label-free and real-time fashion. Lipid membranes constitute the primary biological interface mediating cell signaling and interaction with drugs and pathogens. By exploiting the plasmonic field enhancement in the vicinity of engineered and surface-modified nanoantennas, the proposed biosensor is able to capture the vibrational fingerprints of lipid molecules and monitor in real time the formation kinetics of planar biomimetic membranes in aqueous environments. Furthermore, we show that this plasmonic biosensor features high-field enhancement extending over tens of nano meters away from the surface, matching the size of typical bioassays while preserving high sensitivity.

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Type
research article
DOI
10.1021/acs.nanolett.5b05316
Web of Science ID

WOS:000370215200102

Author(s)
Limaj, Odeta
Etezadi, Dordaneh  
Wittenberg, Nathan J.
Rodrigo, Daniel
Yoo, Daehan
Oh, Sang-Hyun
Altug, Hatice  
Date Issued

2016

Publisher

American Chemical Society

Published in
Nano Letters
Volume

16

Issue

2

Start page

1502

End page

1508

Subjects

Surface-enhanced infrared absorption

•

lipid membrane

•

label-free biosensor

•

plasmonics

•

real-time kinetics

•

near-field decay

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
BIOS  
Available on Infoscience
April 1, 2016
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/125393
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