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research article
Enantioselective Access to Spirocyclic Sultams by Chiral Cp-x-Rhodium(III)-Catalyzed Annulations
Chiral spirocyclic sultams are a valuable compound class in organic and medicinal chemistry. A rapid entry to this structural motif involves a [3+2] annulation of an N-sulfonyl ketimine and an alkyne. Although the directing-group properties of the imino group for C-H activation have been exploited, the developments of related asymmetric variants have remained very challenging. The use of rhodium(III) complexes equipped with a suitable atropchiral cyclopentadienyl ligand, in conjunction with a carboxylic acid additive, enables an enantioselective and high yielding access to such spirocyclic sultams.
Type
research article
Web of Science ID
WOS:000369855000011
Authors
Publication date
2016
Publisher
Published in
Volume
22
Issue
7
Start page
2270
End page
2273
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
April 1, 2016
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