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research article
The mechanisms of spatial and temporal patterning of cell-edge dynamics
Adherent cells migrate and change their shape by means of protrusion and retraction at their edges. When and where these activities occur defines the shape of the cell and the way it moves. Despite a great deal of knowledge about the structural organization, components, and biochemical reactions involved in protrusion and retraction, the origins of their spatial and temporal patterns are still poorly understood. Chemical signaling circuitry is believed to be an important source of patterning, but recent studies highlighted mechanisms based on physical forces, motion, and mechanical feedback.
Type
research article
Web of Science ID
WOS:000364577600016
Authors
Publication date
2015
Publisher
Published in
Volume
36
Start page
113
End page
121
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
February 16, 2016
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