Nowadays, digital enterprises are confronted with disruptive technological advancements in their constant quest for innovation and creativity. In order to evolve towards new forms of enterprises, driven by constant business model transformation, a number of challenges need to be addressed from a research and practice perspective. In this paper, a glimpse of the technological trends and visionary scenarios for Enterprises of the Future is provided, leading to the elaboration of the research challenges along the following dimensions: (a) Collaborative, Real-time, Proactive Business Analytics-as-a-Service, (b) Innovative, Web-based Business Models for New Kinds of Economies, (c) Federated, Innovation-driven Enterprise Collaboration Platforms, (d) Dynamic Discovery and Negotiation of the Intellectual Property Rights' Flow.