TADDOL-based phosphorus(III)-ligands in enantioselective Pd(0)-catalysed C-H functionalisations
Monodentate TADDOL-derived phosphoramidites and phosphonites are versatile chiral ligands for enantio-selective Pd(0)-catalysed C-H functionalisations. They enable highly selective cyclisations to access a wide range of chiral carbo-and heterocycles. The high attractiveness of this ligand class consists in their modular structure, allowing for a quick assembly of a library with variable steric properties. Asymmetric C-H functionalisation methods utilising catalytic systems based on Pd(0) complexes and TADDOL-type ligands are presented and aspects of selectivity are discussed.
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Pedroni, J., & Cramer, N. (2015). TADDOL-based phosphorus(III)-ligands in enantioselective Pd(0)-catalysed C-H functionalisations. Chemical Communications (ChemComm), 51(100), 17647–17657. https://doi.org/10.1039/c5cc07929b
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WOS:000366664300001
2015
51
100
17647
17657
REVIEWED
EPFL