TADDOL-based phosphorus(III)-ligands in enantioselective Pd(0)-catalysed C-H functionalisations

Monodentate TADDOL-derived phosphoramidites and phosphonites are versatile chiral ligands for enantio-selective Pd(0)-catalysed C-H functionalisations. They enable highly selective cyclisations to access a wide range of chiral carbo-and heterocycles. The high attractiveness of this ligand class consists in their modular structure, allowing for a quick assembly of a library with variable steric properties. Asymmetric C-H functionalisation methods utilising catalytic systems based on Pd(0) complexes and TADDOL-type ligands are presented and aspects of selectivity are discussed.


Published in:
Chemical Communications, 51, 100, 17647-17657
Year:
2015
Publisher:
Cambridge, Royal Society of Chemistry
ISSN:
1359-7345
Laboratories:




 Record created 2016-02-16, last modified 2018-03-17


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