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  4. Biomechanical Role of Bone Anisotropy Estimated on Clinical CT Scans by Image Registration
 
research article

Biomechanical Role of Bone Anisotropy Estimated on Clinical CT Scans by Image Registration

Taghizadeh, Elham
•
Reyes, Mauricio
•
Zysset, Philippe
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2016
Annals of Biomedical Engineering

Image-based modeling is a popular approach to perform patient-specific biomechanical simulations. Accurate modeling is critical for orthopedic application to evaluate implant design and surgical planning. It has been shown that bone strength can be estimated from the bone mineral density (BMD) and trabecular bone architecture. However, these findings cannot be directly and fully transferred to patient-specific modeling since only BMD can be derived from clinical CT. Therefore, the objective of this study was to propose a method to predict the trabecular bone structure using a A mu CT atlas and an image registration technique. The approach has been evaluated on femurs and patellae under physiological loading. The displacement and ultimate force for femurs loaded in stance position were predicted with an error of 2.5% and 3.7%, respectively, while predictions obtained with an isotropic material resulted in errors of 7.3% and 6.9%. Similar results were obtained for the patella, where the strain predicted using the registration approach resulted in an improved mean squared error compared to the isotropic model. We conclude that the registration of anisotropic information from of a single template bone enables more accurate patient-specific simulations from clinical image datasets than isotropic model.

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Type
research article
DOI
10.1007/s10439-016-1551-4
Web of Science ID

WOS:000379511100015

Author(s)
Taghizadeh, Elham
Reyes, Mauricio
Zysset, Philippe
Latypova, Adeliya  
Terrier, Alexandre  
Büchler, Philippe
Date Issued

2016

Publisher

Springer Verlag

Published in
Annals of Biomedical Engineering
Volume

44

Issue

8

Start page

2505

End page

2517

Subjects

Trabecular bone

•

Femur

•

Patella

•

Anisotropy

•

Finite element analysis (FEA)

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
LBO  
Available on Infoscience
January 25, 2016
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/122629
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