A microcalorimetric platform for studying the heat produced by chemical reactions in microliter volumes

We describe the development of a microcalorimetric platform for accurate measurement of the heat power generated by chemical/biochemical reactions in liquid volumes of a few 10 µL, which we used to measure the heat of mixing of 1-propanol in deionized water. The system allows fast overall stabilization to a setpoint temperature with a stability of ± 1 mK. The combination of an open-well sample reservoir with a commercial nanocalorimetric chip (Xensor Integration) makes the platform easy to use and very versatile. The open-well format allows preloading a sample by pipetting, while fluidic interconnections enable injecting subsequently additional reagents.


Published in:
Conference Proceedings, 1861-1863
Presented at:
19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Gyeongju, Korea, October 25-29, 2015
Year:
2015
Keywords:
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 Record created 2016-01-04, last modified 2018-09-13

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