Local GABA Circuit Control of Experience-Dependent Plasticity in Developing Visual Cortex

Sensory experience in early life shapes the mammalian brain. An impairment in the activity-dependent refinement of functional connections within developing visual cortex was identified here in a mouse model. Gene-targeted disruption of one isoform of glutamic acid decarboxylase prevented the competitive loss of responsiveness to an eye briefly deprived of vision, without affecting cooperative mechanisms of synapse modification in vitro. Selective, use-dependent enhancement of fast intracortical inhibitory transmission with benzodiazepines restored plasticity in vivo, rescuing the genetic defect. Specific networks of inhibitory interneurons intrinsic to visual cortex may detect perturbations in sensory input to drive experience-dependent plasticity during development.

Published in:
Science, 282, 5393, 1504-1508
American Association for the Advancement of Science

Note: The status of this file is: EPFL only

 Record created 2015-12-02, last modified 2018-01-28

External link:
Download fulltext
Publisher's version
Rate this document:

Rate this document:
(Not yet reviewed)