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  4. The DNA-Uptake Process of Naturally Competent Vibrio cholerae
 
review article

The DNA-Uptake Process of Naturally Competent Vibrio cholerae

Matthey, Noémie  
•
Blokesch, Melanie  
2016
Trends in Microbiology

The sophisticated DNA-uptake machinery used during natural transformation is still poorly characterized, especially in Gram-negative bacteria where the transforming DNA has to cross two membranes as well as the peptidoglycan layer before entering into the cytoplasm. The DNA-uptake machinery was hypothesized to take the form of a pseudopilus, which, upon repeated cycles of extension and retraction, would pull external DNA towards the cell surface or into the periplasmic space, followed by translocation across the cytoplasmic membrane. In this review, we summarize recent advances on the DNA-uptake machinery of V. cholerae, highlighting the presence of an extended competence-induced pilus and the contribution of a conserved DNA-binding protein that acts as a ratchet and reels DNA into the periplasm.

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Type
review article
DOI
10.1016/j.tim.2015.10.008
Web of Science ID

WOS:000369550600008

Author(s)
Matthey, Noémie  
Blokesch, Melanie  
Date Issued

2016

Publisher

Elsevier

Published in
Trends in Microbiology
Volume

24

Issue

2

Start page

98

End page

110

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
UPBLO  
Available on Infoscience
November 27, 2015
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/120839
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