000213205 001__ 213205
000213205 005__ 20180913063406.0
000213205 037__ $$aPOST_TALK
000213205 245__ $$aInfluence of Right and Left Atrial Tissue Heterogeneity on Atrial Fibrillation Perpetuation
000213205 269__ $$a2015
000213205 260__ $$c2015
000213205 336__ $$aPosters
000213205 520__ $$aWe propose a biophysical modelling approach to separately investigate the impact of right and left atrial (RA/LA) electrical heterogeneity on atrial fibrillation (AF) perpetuation. The baseline AF substrate was based on a 4:1 anisotropy ratio and uniform membrane properties. AF was initiated by a ramp-pacing protocol applied in the pulmonary veins region. Once AF was observed, random patchy heterogeneities in action potential duration (shorter duration inside the patches) were introduced in the cellular model for the subsequent simulation of AF. The effect of tissue heterogeneity on AF perpetuation was quantified by the duration of AF episodes (an AF episode lasting more than 50 s was considered as sustained). For high percentages of heterogeneities, the mean AF episode duration and the number of non-terminated AF episodes were significantly higher for the RA compared to the LA. This could be indicative of a very probable involvement of the RA substrate into the persistent AF process in this model. A direct link between the spatial localization of tissue heterogeneity and AF duration was also observed.
000213205 6531_ $$aatrial fibrillation
000213205 6531_ $$abiophysical model of the human atria
000213205 6531_ $$aelectrical heterogeneity
000213205 700__ $$0247370$$aLuca, Adrian$$g239215
000213205 700__ $$aJacquemet, Vincent
000213205 700__ $$aVirag, Nathalie
000213205 700__ $$0240458$$aVesin, Jean-Marc$$g106643
000213205 7112_ $$aComputing in Cardiology$$cNice, France$$dSeptember 6-9, 2015
000213205 909C0 $$0252331$$pASPG
000213205 909CO $$ooai:infoscience.tind.io:213205$$pSTI$$pposter
000213205 917Z8 $$x239215
000213205 937__ $$aEPFL-POSTER-213205
000213205 973__ $$aEPFL
000213205 980__ $$aPOSTER