The importance of dynamics in integrative modeling of supramolecular assemblies

Revealing the atomistic architecture of supramolecular complexes is a fundamental step toward a deeper understanding of cellular functioning. To date, this formidable task is facilitated by an emerging array of integrative modeling approaches that combine experimental data from different sources. One major challenge these methods have to face is the treatment of the dynamic rearrangements of the individual subunits upon assembly. While this flexibility can be sampled at different levels, integrating native dynamic determinants with available experimental inputs can provide an effective way to reveal the molecular recognition mechanisms at the basis of supramolecular assembly.


Published in:
Current Opinion In Structural Biology, 31, 28-34
Year:
2015
Publisher:
London, Current Biology Ltd
ISSN:
0959-440X
Laboratories:




 Record created 2015-09-28, last modified 2018-03-17


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