Development of an in situ controllable polymerization tool and process for hydrogel used to replace nucleus pulposus

Currently implants or tissue replacements are inserted either as a whole implant or by injecting a liquid which polymerizes to form a solid implant at the appropriate location. This is either highly invasive or not controllable. We developed a tool to perform such surgeries in a minimally invasive and controllable way. It combines photopolymerization and fluorescence spectroscopy in a surgical apparatus. However, to successfully replace tissue such as cartilage or an intervertebral disc, photopolymerizable materials do not only need to be photoactive. They should also be able to withstand the environmental loading conditions after implantation. Therefore we developed a set of in situ and in vitro tests adapted to the evaluation of photopolymerized tissue replacements and implants. In particular in this article, we report on a method, which combines photopolymerization and photorheology to track the current state of polymer during photopolymerization.


Editor(s):
Kurachi, C
Svanberg, K
Tromberg, Bj
Bagnato, Vs
Published in:
Biophotonics South America, 9531, 953115
Presented at:
Joint Meeting of the 1st SPIE Conference on Biophotonics South America (BSA) / 15th World Congress of the International-Photodynamic-Association (IPA), Rio de Janeiro, BRAZIL, MAY 23-25, 2015
Year:
2015
Publisher:
Bellingham, Spie-Int Soc Optical Engineering
ISSN:
0277-786X
ISBN:
978-1-62841-696-1
Keywords:
Laboratories:




 Record created 2015-09-28, last modified 2018-03-18


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