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  4. Synthesis and Antiproliferative Activity of New Ruthenium Complexes with Ethacrynic-Acid-Modified Pyridine and Triphenylphosphine Ligands
 
research article

Synthesis and Antiproliferative Activity of New Ruthenium Complexes with Ethacrynic-Acid-Modified Pyridine and Triphenylphosphine Ligands

Agonigi, Gabriele
•
Riedel, Tina  
•
Zacchini, Stefano
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2015
Inorganic Chemistry

Pyridine- and phosphine-based ligands modified with ethacrynic acid (a broad acting glutathione transferase inhibitor) were prepared and coordinated to ruthenium(II)-arene complexes and to a ruthenium(III) NAMI-A type complex. All the compounds (ligands and complexes) were fully characterized by analytical and spectroscopic methods and, in one case, by single-crystal Xray diffraction. The in vitro anticancer activity of the compounds was studied, with the compounds displaying moderate cytotoxicity toward the human ovarian cancer cell lines. All the complexes led to similar levels of residual GST activity in the different cell lines, irrespective of the stability of the Ru-ligand bond.

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Type
research article
DOI
10.1021/acs.inorgchem.5b00802
Web of Science ID

WOS:000357705800051

Author(s)
Agonigi, Gabriele
Riedel, Tina  
Zacchini, Stefano
Paunescu, Emilia  
Pampaloni, Guido
Bartalucci, Niccolo
Dyson, Paul J.  
Marchetti, Fabio
Date Issued

2015

Publisher

Amer Chemical Soc

Published in
Inorganic Chemistry
Volume

54

Issue

13

Start page

6504

End page

6512

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LCOM  
Available on Infoscience
September 28, 2015
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/118953
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