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review article
NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus
2015
NAD(+) has emerged as a vital cofactor that can rewire metabolism, activate sirtuins, and maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded protein response. This improved understanding of NAD(+) metabolism revived interest in NAD(+)-boosting strategies to manage a wide spectrum of diseases, ranging from diabetes to cancer. In this review, we summarize how NAD(+) metabolism links energy status with adaptive cellular and organismal responses and how this knowledge can be therapeutically exploited.
Type
review article
Web of Science ID
WOS:000357656900006
Authors
Publication date
2015
Publisher
Published in
Volume
22
Issue
1
Start page
31
End page
53
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
September 28, 2015
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