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  4. Parasite Proximity Drives the Expansion of Regulatory T Cells in Peyer's Patches following Intestinal Helminth Infection
 
research article

Parasite Proximity Drives the Expansion of Regulatory T Cells in Peyer's Patches following Intestinal Helminth Infection

Mosconi, Ilaria  
•
Dubey, Lalit Kumar  
•
Volpe, Beatrice  
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2015
Infection And Immunity

Helminth infections are typically chronic in nature; however, the exact molecular mechanisms by which these parasites promote or thwart host immunity remain unclear. Worm expulsion requires the differentiation of CD4(+) T cells into Th2 cells, while regulatory T cells (Tregs) act to dampen the extent of the Th2 response. Priming of T cells requires drainage or capture of antigens within lymphoid tissues, and in the case of intestinal helminths, such sites include the mucosa-associated Peyer's patches (PPs) and the draining mesenteric lymph nodes (MLN). To gain insight into when and where the activation of the adaptive T cell response takes place following intestinal helminth infection, we analyzed Th2 and Treg responses in the PPs and MLN following infection with the murine intestinal helminth Heligmosomoides polygyrus bakeri. Protective Th2 responses were observed to be largely restricted to the MLN, while a greater expansion of Tregs occurred within the PPs. Interestingly, those PPs that formed a contact with the parasite showed the greatest degree of Treg expansion and no evidence of type 2 cytokine production, indicating that the parasite may secrete products that act in a local manner to selectively promote Treg expansion. This view was supported by the finding that H. polygyrus bakeri larvae could promote Treg proliferation in vitro. Taken together, these data indicate that different degrees of Treg expansion and type 2 cytokine production occur within the PPs and MLN following infection with the intestinal helminth H. polygyrus bakeri and indicate that these organs exhibit differential responses following infection with intestinal helminths.

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Type
research article
DOI
10.1128/Iai.00266-15
Web of Science ID

WOS:000359435600030

PubMed ID

26150538

Author(s)
Mosconi, Ilaria  
Dubey, Lalit Kumar  
Volpe, Beatrice  
Esser-Von Bieren, Julia
Zaiss, Mario M.  
Lebon, Luc
Massacand, Joanna C.
Harris, Nicola L.  
Date Issued

2015

Publisher

American Society for Microbiology

Published in
Infection And Immunity
Volume

83

Issue

9

Start page

3657

End page

3665

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
UPHARRIS  
Available on Infoscience
September 28, 2015
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/118737
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