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research article

Anticancer Organometallic Osmium(II)-p-cymene Complexes

Paunescu, Emilia  
•
Nowak-Sliwinska, Patrycja  
•
Clavel, Catherine M.  
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2015
Chemmedchem

Osmium compounds are attracting increasing attention as potential anticancer drugs. In this context, a series of bifunctional organometallic osmium(II)-p-cymene complexes functionalized with alkyl or perfluoroalkyl groups were prepared and screened for their antiproliferative activity. Three compounds from the series display selectivity toward cancer cells, with moderate cytotoxicity observed against human ovarian carcinoma (A2780) cells, whereas no cytotoxicity was observed on non-cancerous human embryonic kidney (HEK-293) cells and human endothelial (ECRF24) cells. Two of these three cancer-cell-selective compounds induce cell death largely via apoptosis and were also found to disrupt vascularization in the chicken embryo chorioallantoic membrane (CAM) model. Based on these promising properties, these compounds have potential clinical applications.

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Type
research article
DOI
10.1002/cmdc.201500221
Web of Science ID

WOS:000360499400011

Author(s)
Paunescu, Emilia  
Nowak-Sliwinska, Patrycja  
Clavel, Catherine M.  
Scopelliti, Rosario  
Griffioen, Arjan W.
Dyson, Paul J.  
Date Issued

2015

Publisher

Wiley-V C H Verlag Gmbh

Published in
Chemmedchem
Volume

10

Issue

9

Start page

1539

End page

1547

Subjects

antitumor agents

•

bioorganometallic chemistry

•

chorioallantoic membrane model

•

osmium complexes

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LCOM  
Available on Infoscience
September 28, 2015
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/118707
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