Method for the nmr based determination of the affinity of drugs for a target protein

The document relates to a method for the determination of the binding properties of at least one first chemical compound to at least one second chemical compound between a free essentially dissociated state and a bound essentially associated state by using nuclear magnetic resonance (NMR) measurements, wherein at least one of the first chemical compound or the second chemical compound comprises two coupled 1/2 spins in inequivalent molecular sites, wherein the relaxation of a long-lived state of the spin pair is measured as a function of the concentration of at least one of said first chemical compound for the determination of the equilibrium constant (KD) between the free state and the bound state.

Other identifiers:
TTO: 6.1131
EPO Family ID: 45217529

 Record created 2015-09-22, last modified 2018-09-13

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