A method for producing hyperpolarized sample material for use in magnetic resonance investigations, with a) preparing a target material, containing high gamma nuclei with a short T1, - a polarizing agent with a broad EPR line, and low gamma nuclei with a long T1, b) irradiating the polarizing agent in the target material with microwave radiation, wherein the target material is at a cryogenic temperature and exposed to a static magnetic field B0>= 4.0 T, thus polarizing the high gamma nuclei by DNP, c) transferring the polarization from the high gamma nuclei to the low gamma nuclei by Cross Polarization, d) preparing a dissolved sample material containing the hyperpolarized low y nuclei from the target material. With the inventive method, nuclei with a long longitudinal relaxation time T1 can be quickly hyperpolarized to a high polarization level.
48087581
Alternative title(s) : (de) Verfahren und vorrichtung fĂ¼r schnelle dnp (fr) MĂ©thode et dispositif pour pdn rapide
TTO:6.0605.10
Patent number | Country code | Kind code | Date issued |
US9329245 | US | B2 | 2016-05-03 |
EP2836849 | EP | B1 | 2016-03-02 |
EP2836849 | EP | A1 | 2015-02-18 |
US2013274111 | US | A1 | 2013-10-17 |
WO2013153101 | WO | A1 | 2013-10-17 |