Triblock copolymers for cytoplasmic delivery of gene-based drugs
The invention features a triblock copolymer including a hydrophilic block a hydrophobic block and a positively charged block capable of reversibly complexing a negatively charged molecule, e.g., a nucleic acid, wherein the hydrophobic block is disposed between the hydrophilic block and the positively charged block. Desirably, the triblock copolymer is capable of self-assembling into a supramolecular structure, such as a micelle or vesicle. The invention further features methods of delivering negatively charged molecules and methods of treating a disease or condition using the polymers of the invention.
37637653
Alternative title(s) : (de) Triblock-copolymere zur zytoplasmischen verabreichung gen-basierter arzneimittel (fr) Copolymères triblocs pour la fourniture cytoplasmique de médicaments à base de gènes
TTO:6.0596
Patent number | Country code | Kind code | Date issued |
EP2298829 | EP | B1 | 2017-09-20 |
US9505867 | US | B2 | 2016-11-29 |
EP1891141 | EP | B1 | 2016-11-16 |
JP5329949 | JP | B2 | 2013-10-30 |
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US2010222407 | US | A1 | 2010-09-02 |
JP2008542500 | JP | A | 2008-11-27 |
EP1891141 | EP | A4 | 2008-07-02 |
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