Hyperpolarized 6Li as a probe for hemoglobin oxygenation level

• Published in: Contrast Media and Molecular Imaging, vol. 11, num. 1, p. 41-46
• Hoboken: Wiley-Blackwell, 2016

Hyperpolarization by dissolution dynamic nuclear polarization (DNP) is a versatile technique to dramatically enhance the nuclear magnetic resonance (NMR) signal intensity of insensitive long-T1 nuclear spins such as 6 Li. The 6 Li longitudinal relaxation of lithium ions in aqueous solutions strongly depends on the concentration of paramagnetic species, even if they are present in minute amounts. We herein demonstrate that blood oxygenation can be readily detected by taking advantage of the 6 Li signal enhancement provided by dissolution DNP, together with the more than 10% decrease in 6 Li longitudinal relaxation as a consequence of the presence of paramagnetic deoxyhemoglobin.

Keywords: CIBM-AIT

Reference

• EPFL-ARTICLE-210488
• doi:10.1002/cmmi.1656
• View record in Web of Science

Record created on 2015-08-12, modified on 2017-05-12