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research article

Finite element and finite volume-element simulation of pseudo-ECGs and cardiac alternans

Dupraz, Marie
•
Filippi, Simonetta
•
Gizzi, Alessio
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2015
Mathematical Methods in the Applied Sciences

In this paper, we are interested in the spatio-temporal dynamics of the transmembrane potential in paced isotropic and anisotropic cardiac tissues. In particular, we observe a specific precursor of cardiac arrhythmias that is the presence of alternans in the action potential duration. The underlying mathematical model consists of a reaction–diffusion system describing the propagation of the electric potential and the nonlinear interaction with ionic gating variables. Either conforming piecewise continuous finite elements or a finite volume-element scheme are employed for the spatial discretization of all fields, whereas operator splitting strategies of first and second order are used for the time integration. We also describe an efficient mechanism to compute pseudo-ECG signals, and we analyze restitution curves and alternans patterns for physiological and pathological cardiac rhythms.

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Type
research article
DOI
10.1002/mma.3127
Web of Science ID

WOS:000351741800004

Author(s)
Dupraz, Marie
Filippi, Simonetta
Gizzi, Alessio
Quarteroni, Alfio  
Ruiz-Baier, Ricardo  
Date Issued

2015

Publisher

Wiley-Blackwell

Published in
Mathematical Methods in the Applied Sciences
Volume

38

Issue

6

Start page

1046

End page

1058

Subjects

finite element discretization

•

finite volume-element method

•

reaction–diffusion system

•

operator splitting

•

cardiac alternans

•

pseudo-ECG

•

spatio-temporal dynamics

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
CMCS  
Available on Infoscience
May 27, 2015
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/114074
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