Miniature and sub-miniature samples were used for determination of mechanical properties of materials for advanced fission plants. Results from indentation and focused ion beam prepared micro-samples, punch tests and thin strip (irradiation) creep tests are shown. The results allow conclusions concerning materials damage. Irradiation damage profiles were determined with indentation. Results from micro-pillar tests showed a good agreement with results from conventional samples in case of oxide dispersion strengthened steels. Thin strip irradiation creep experiments revealed a negligible influence of dispersoid size/distribution on creep rates. Punch tests of fibre reinforced materials showed consistent results which still need quantitative analysis.