Repository logo

Infoscience

  • English
  • French
Log In
Logo EPFL, École polytechnique fédérale de Lausanne

Infoscience

  • English
  • French
Log In
  1. Home
  2. Academic and Research Output
  3. Journal articles
  4. Multicontrast connectometry: A new tool to assess cerebellum alterations in early relapsing‐remitting multiple sclerosis
 
research article

Multicontrast connectometry: A new tool to assess cerebellum alterations in early relapsing‐remitting multiple sclerosis

Romascano, David Paul Roger  
•
Meskaldji, Djalel Eddine  
•
Bonnier, Guillaume  
Show more
2015
Human Brain Mapping

Background: Cerebellar pathology occurs in late multiple sclerosis (MS) but little is known about cerebellar changes during early disease stages. In this study, we propose a new multicontrast “connectometry” approach to assess the structural and functional integrity of cerebellar networks and connectivity in early MS. Methods: We used diffusion spectrum and resting-state functional MRI (rs-fMRI) to establish the structural and functional cerebellar connectomes in 28 early relapsing-remitting MS patients and 16 healthy controls (HC). We performed multicontrast “connectometry” by quantifying multiple MRI parameters along the structural tracts (generalized fractional anisotropy-GFA, T1/T2 relaxation times and magnetization transfer ratio) and functional connectivity measures. Subsequently, we assessed multivariate differences in local connections and network properties between MS and HC subjects; finally, we correlated detected alterations with lesion load, disease duration, and clinical scores. Results: In MS patients, a subset of structural connections showed quantitative MRI changes suggesting loss of axonal microstructure and integrity (increased T1 and decreased GFA, P < 0.05). These alterations highly correlated with motor, memory and attention in patients, but were independent of cerebellar lesion load and disease duration. Neither network organization nor rs-fMRI abnormalities were observed at this early stage. Conclusion: Multicontrast cerebellar connectometry revealed subtle cerebellar alterations in MS patients, which were independent of conventional disease markers and highly correlated with patient function. Future work should assess the prognostic value of the observed damage.

  • Details
  • Metrics
Type
research article
DOI
10.1002/hbm.22698
Web of Science ID

WOS:000351737800028

Author(s)
Romascano, David Paul Roger  
Meskaldji, Djalel Eddine  
Bonnier, Guillaume  
Simioni, Samanta
Rotzinger, David
Lin, Ying-Chia
Menegaz, Gloria
Roche, Alexis  
Schluep, Myriam
Du Pasquier, Renaud
Show more
Date Issued

2015

Publisher

Wiley-Blackwell

Published in
Human Brain Mapping
Volume

36

Start page

1609

End page

1619

Subjects

connectometry

•

multicontrast

•

diffusion MRI

•

resting-state MRI

•

multiple sclerosis

•

LTS5

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LTS5  
Available on Infoscience
March 22, 2015
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/112654
Logo EPFL, École polytechnique fédérale de Lausanne
  • Contact
  • infoscience@epfl.ch

  • Follow us on Facebook
  • Follow us on Instagram
  • Follow us on LinkedIn
  • Follow us on X
  • Follow us on Youtube
AccessibilityLegal noticePrivacy policyCookie settingsEnd User AgreementGet helpFeedback

Infoscience is a service managed and provided by the Library and IT Services of EPFL. © EPFL, tous droits réservés