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review article

Telomere functions grounding on TERRA firma

Azzalin, Claus M.
•
Lingner, Joachim  
2015
Trends In Cell Biology

Long noncoding telomeric repeat-containing RNAs TERRAs - are transcribed in a regulated manner from telomeres throughout eukaryotes. TERRA molecules consist of chromosome end-specific subtelomeric sequences and telomeric repeats at their 3' ends. Recent work suggests that TERRA sustains several important functions at chromosome ends. TERRA can regulate telomere length through modulation of exonuclease 1 and telomerase, it may promote recruitment of chromatin modifiers to damaged telomeres and thereby enable DNA end-processing, and it may promote telomere protein composition changes during cell cycle progression. Furthermore, telomere transcription regulates chromosome-end mobility within the nucleus. We review how TERRA, by regulated expression and by providing a molecular scaffold for various protein enzymes, can support a large variety of vital functions.

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Type
review article
DOI
10.1016/j.tcb.2014.08.007
Web of Science ID

WOS:000347863600004

Author(s)
Azzalin, Claus M.
Lingner, Joachim  
Date Issued

2015

Publisher

Elsevier Science London

Published in
Trends In Cell Biology
Volume

25

Issue

1

Start page

29

End page

36

Subjects

TERRA

•

long noncoding RNA

•

telomeres

•

chromatin

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
UPLIN  
Available on Infoscience
February 20, 2015
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/111324
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