Combinatorial Screening for Specific Drug Solubilizers with Switchable Release Profiles

Polymer-block-peptide conjugates are tailored to render hydrophobic small molecule drugs water soluble. The combinatorial strategy selects for bioconjugates that exhibit sequence-specific solubilization and switchable release profiles of the cargo through incorporation of a disulfide linker moiety into the peptide-library design. While the study focused on the photosensitizer m-THPC and reductive carrier cleavage, the approach is generic and might be expanded toward a broad range of poorly soluble small-molecule drugs and other selective cleavage mechanisms to disassemble a peptide binding domain of the bioconjugate-based solubilizer.


Published in:
Macromolecular Bioscience, 15, 1, 82-89
Year:
2015
Publisher:
Weinheim, Wiley-V C H Verlag Gmbh
ISSN:
1616-5187
Keywords:
Laboratories:




 Record created 2015-02-20, last modified 2018-03-17


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