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research article
Palladium-Catalyzed Aminocarbonylation of Alkynes to Succinimides
Succinimide derivatives are useful building blocks for the synthesis of natural products and drugs. We describe an efficient route to succinimide derivatives comprising Pd(xantphos)Cl2-catalyzed aminocarbonylation of alkynes with aromatic or aliphatic amines in the presence of p-TsOH. The utility of this route is demonstrated with the synthesis of a large number of succinimide compounds including an important photochromic molecule.
Type
research article
Web of Science ID
WOS:000347506400038
Authors
Publication date
2015
Publisher
Published in
Volume
80
Issue
1
Start page
386
End page
391
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
February 20, 2015
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