Palladium-Catalyzed Aminocarbonylation of Alkynes to Succinimides

Succinimide derivatives are useful building blocks for the synthesis of natural products and drugs. We describe an efficient route to succinimide derivatives comprising Pd(xantphos)Cl2-catalyzed aminocarbonylation of alkynes with aromatic or aliphatic amines in the presence of p-TsOH. The utility of this route is demonstrated with the synthesis of a large number of succinimide compounds including an important photochromic molecule.


Published in:
Journal Of Organic Chemistry, 80, 1, 386-391
Year:
2015
Publisher:
Washington, Amer Chemical Soc
ISSN:
0022-3263
Laboratories:




 Record created 2015-02-20, last modified 2018-03-17


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