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research article
Enantioselective Synthesis of Putative Lipiarmycin Aglycon Related to Fidaxomicin/Tiacumicin B
An enantioselective synthesis of a putative lipiarmycin aglycon was accomplished and features: 1) Brown’s enantioselective alkoxyallylboration and allylation of aldehydes, 2) chain elongation by iterative Horner–Wadsworth– Emmons olefination, 3) Evans aldol reaction and 4) an enediene ring-closing metathesis. A neighboring-group-assisted chemoselective reductive desilylation was uncovered in this study and was instrumental to the realization of the present synthesis.
Type
research article
Web of Science ID
WOS:000349209200048
Authors
Publication date
2015
Publisher
Published in
Volume
54
Issue
6
Start page
1929
End page
1932
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
February 2, 2015
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