000204224 001__ 204224
000204224 005__ 20190317000055.0
000204224 0247_ $$2doi$$a10.1126/science.1260064
000204224 022__ $$a1095-9203
000204224 02470 $$2ISI$$a000347102300048
000204224 037__ $$aARTICLE
000204224 245__ $$aThe type VI secretion system of Vibrio cholerae fosters horizontal gene transfer
000204224 260__ $$bAmer Assoc Advancement Science$$c2015$$aWashington
000204224 269__ $$a2015
000204224 300__ $$a5
000204224 336__ $$aJournal Articles
000204224 520__ $$aNatural competence for transformation is a common mode of horizontal gene transfer and contributes to bacterial evolution. Transformation occurs through the uptake of external DNA and its integration into the genome. Here, we show that the type VI secretion system (T6SS), which serves as a predatory killing device, is part of the competence regulon in the naturally transformable pathogen Vibrio cholerae. The T6SS-encoding gene cluster is under the positive control of the competence regulators TfoX and QstR and is induced by growth on chitinous surfaces. Live-cell imaging revealed that deliberate killing of non-immune cells, via competence-mediated induction of T6SS, releases DNA and makes it accessible for horizontal gene transfer in V. cholerae.
000204224 700__ $$aBorgeaud, S.
000204224 700__ $$aMetzger, L. C.
000204224 700__ $$aScrignari, T.
000204224 700__ $$g192269$$aBlokesch, M.$$0243611
000204224 773__ $$j347$$tScience$$k6217$$q63-67
000204224 8564_ $$uhttp://www.sciencemag.org/content/347/6217/63.full$$zURL
000204224 909C0 $$xU12076$$0252246$$pUPBLO
000204224 909CO $$qGLOBAL_SET$$pSV$$ooai:infoscience.tind.io:204224$$particle
000204224 917Z8 $$x192269
000204224 937__ $$aEPFL-ARTICLE-204224
000204224 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000204224 980__ $$aARTICLE