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  4. Time-resolved imaging system for fluorescence-guided surgery with lifetime imaging capability
 
conference paper

Time-resolved imaging system for fluorescence-guided surgery with lifetime imaging capability

Powolny, F.  
•
Homicsko, K.
•
Sinisi, R.
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Popp, J
•
Tuchin, Vv
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2014
Biophotonics: Photonic Solutions For Better Health Care Iv
Conference on Biophotonics - Photonic Solutions for Better Health Care IV

We present a single-photon camera for fluorescence imaging, with a time resolution better than 100ps, capable of providing both intensity and lifetime images. the camera was fabricated in standard CMOS technology. With this FluoCam we show the possibility to study sub-nanosecond fluorescence mechanisms. The FluoCam was used to characterize a near-infrared probe, indocyanine green, conjugated with multimeric cyclic pentapeptide ( cRGD). The fluorescent probe-conjugated was used to target and mark tumors with better specificity, in particular aiming at targeting the integrins alpha(v)beta(3) and alpha(v)beta(5). As a first step towards clinical studies, preliminary results obtained in-vivo are presented. The first envisioned clinical application would be image-guided surgical oncology to help the surgeon to remove tumor tissue by a better discrimination from normal tissues and also to improve the detection of metastatic lymph nodes. A further application could be the in-vivo determination of the alpha(v)beta(3) and alpha(v)beta(5) targets to select patients for therapy with RGD-chemotherapy conjugates.

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Type
conference paper
DOI
10.1117/12.2052411
Web of Science ID

WOS:000343438000076

Author(s)
Powolny, F.  
Homicsko, K.
Sinisi, R.
Bruschini, C.  
Grigoriev, E.
Homulle, H.
Prior, J. O.
Hanahan, D.
Dubikovskaya, E.
Charbon, E.  
Editors
Popp, J
•
Tuchin, Vv
•
Matthews, Dl
•
Pavone, Fs
Date Issued

2014

Publisher

Spie-Int Soc Optical Engineering

Publisher place

Bellingham

Published in
Biophotonics: Photonic Solutions For Better Health Care Iv
ISBN of the book

978-1-62841-077-8

Total of pages

6

Series title/Series vol.

Proceedings of SPIE

Volume

9129

Subjects

Single Photon Avalanche Diodes (SPADs)

•

Fluorescence Lifetime Imaging

•

Indocyanine green (ICG)

•

Image-guided surgery

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
AQUA  
LCBIM  
Event nameEvent placeEvent date
Conference on Biophotonics - Photonic Solutions for Better Health Care IV

Brussels, BELGIUM

APR 14-17, 2014

Available on Infoscience
December 30, 2014
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/109860
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