As Time Goes by: KRABs Evolve to KAP Endogenous Retroelements

Retroelements, constituting about 50% of the human genome, both contribute to its evolution and threaten its integrity and are thus silenced during development. Jacobs et al. (2014) identify sequence-specific KRAB-ZNF proteins that repress subsets of L1 and SVA retrotransposons in humans, highlighting the evolutionary interplay between retroelements and their hosts.


Published in:
Developmental Cell, 31, 3, 257-258
Year:
2014
Publisher:
Cambridge, Elsevier
ISSN:
1534-5807
Laboratories:




 Record created 2014-12-30, last modified 2018-09-13


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