Repository logo

Infoscience

  • English
  • French
Log In
Logo EPFL, École polytechnique fédérale de Lausanne

Infoscience

  • English
  • French
Log In
  1. Home
  2. Academic and Research Output
  3. Journal articles
  4. Ex situ evaluation of the composition of protein corona of intravenously injected superparamagnetic nanoparticles in rats
 
research article

Ex situ evaluation of the composition of protein corona of intravenously injected superparamagnetic nanoparticles in rats

Sakulkhu, Usawadee  
•
Maurizi, Lionel
•
Mahmoudi, Morteza
Show more
2014
Nanoscale

It is now well recognized that the surfaces of nanoparticles (NPs) are coated with biomolecules (e. g., proteins) in a biological medium. Although extensive reports have been published on the protein corona at the surface of NPs in vitro, there are very few on the in vivo protein corona. The main reason for having very poor information regarding the protein corona in vivo is that separation of NPs from the in vivo environment has not been possible by using available techniques. Knowledge of the in vivo protein corona could lead to better understanding and prediction of the fate of NPs in vivo. Here, by using the unique magnetic properties of superparamagnetic iron oxide NPs (SPIONs), NPs were extracted from rat sera after in vivo interaction with the rat's physiological system. More specifically, the in vivo protein coronas of polyvinyl-alcohol-coated SPIONs with various surface charges are defined. The compositions of the corona at the surface of various SPIONs and their effects on the biodistribution of SPIONs were examined and compared with the corona composition of particles incubated for the same time in rat serum.

  • Details
  • Metrics
Type
research article
DOI
10.1039/c4nr02793k
Web of Science ID

WOS:000345450300046

Author(s)
Sakulkhu, Usawadee  
Maurizi, Lionel
Mahmoudi, Morteza
Motazacker, Mahdi
Vries, Marcel
Gramoun, Azza
Beuzelin, Marie-Gabrielle Ollivier
Vallee, Jean-Paul
Rezaee, Farhad
Hofmann, Heinrich  
Date Issued

2014

Publisher

Royal Soc Chemistry

Published in
Nanoscale
Volume

6

Issue

19

Start page

11439

End page

11450

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LTP  
Available on Infoscience
December 30, 2014
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/109521
Logo EPFL, École polytechnique fédérale de Lausanne
  • Contact
  • infoscience@epfl.ch

  • Follow us on Facebook
  • Follow us on Instagram
  • Follow us on LinkedIn
  • Follow us on X
  • Follow us on Youtube
AccessibilityLegal noticePrivacy policyCookie settingsEnd User AgreementGet helpFeedback

Infoscience is a service managed and provided by the Library and IT Services of EPFL. © EPFL, tous droits réservés