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  4. Improved statistical evaluation of group differences in connectomes by screening-filtering strategy with application to study maturation of brain connections between childhood and adolescence
 
research article

Improved statistical evaluation of group differences in connectomes by screening-filtering strategy with application to study maturation of brain connections between childhood and adolescence

Meskaldji, Djalel Eddine  
•
Vasung, Lana
•
Romascano, David Paul Roger  
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2015
Neuroimage

Detecting local differences between groups of connectomes is a great challenge in neuroimaging, because the large number of tests that have to be performed and the impact on multiplicity correction. Any available information should be exploited to increase the power of detecting true between-group effects. We present an adaptive strategy that exploits the data structure and the prior information concerning positive dependence between nodes and connections, without relying on strong assumptions. As a first step, we decompose the brain network, i.e., the connectome, into subnetworks and we apply a screening at the subnetwork level. The subnetworks are defined either according to prior knowledge or by applying a data driven algorithm. Given the results of the screening step, a filtering is performed to seek real differences at the node/connection level. The proposed strategy could be used to strongly control either the family-wise error rate or the false discovery rate. We show by means of different simulations the benefit of the proposed strategy, and we present a real application of comparing connectomes of preschool children and adolescents.

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Type
research article
DOI
10.1016/j.neuroimage.2014.11.059
Web of Science ID

WOS:000349618600027

Author(s)
Meskaldji, Djalel Eddine  
Vasung, Lana
Romascano, David Paul Roger  
Thiran, Jean-Philippe  
Hagmann, Patric
Morgenthaler, Stephan  
Van De Ville, Dimitri  
Date Issued

2015

Publisher

Elsevier

Published in
Neuroimage
Volume

108

Start page

251

End page

264

Subjects

Multiple testing

•

Complex networks

•

Brain connectivity

•

FWER

•

FDR

•

Adolescence

•

Fronto limbic circuity

•

cibm-spc

•

LTS5

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
MIPLAB  
CNP  
STAP  
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Available on Infoscience
December 8, 2014
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/109245
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