Convergent evolution of complex regulatory landscapes and pleiotropy at Hox loci

Hox genes are required during the morphogenesis of both vertebrate digits and external genitals. We investigated whether transcription in such distinct contexts involves a shared enhancer-containing landscape. We show that the same regulatory topology is used, yet with some tissue-specific enhancer-promoter interactions, suggesting the hijacking of a regulatory backbone from one context to the other. In addition, comparable organizations are observed at both HoxA and HoxD clusters, which separated through genome duplication in an ancestral invertebrate animal. We propose that this convergent regulatory evolution was triggered by the preexistence of some chromatin architecture, thus facilitating the subsequent recruitment of the appropriate transcription factors. Such regulatory topologies may have both favored and constrained the evolution of pleiotropic developmental loci in vertebrates.


Published in:
Science, 346, 6212, 1004-1006
Year:
2014
Publisher:
Washington, Amer Assoc Advancement Science
ISSN:
1095-9203
Note:
Lonfat, Nicolas Montavon, Thomas Darbellay, Fabrice Gitto, Sandra Duboule, Denis eng Research Support, Non-U.S. Gov't New York, N.Y. 2014/11/22 06:00 Science. 2014 Nov 21;346(6212):1004-6. doi: 10.1126/science.1257493.
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 Record created 2014-11-24, last modified 2018-09-13

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