1H MRS to investigate the hepatic profile of GLUT2-/- mice

We performed 1H MRS at 14.1T in the liver of GLUT2-/- and wild-type (WT) mice. Improved spectral resolution allowed identifying peaks from the lipid resonances, choline containing compounds, taurine and glycogen in WT mice. Performing the same measurements in GLUT2-/- mice revealed a strong contribution from carbohydrates, notably glucose, to the 1H MR liver spectrum. Also a reduced lipid content was detected by 1H MRS in those mice. The characterization of the hepatic profile by 1H MRS in GLUT2-/- mice is of great value to address changes in the main energy fuels in the liver longitudinally.


Presented at:
Joint Annual Meeting ISMRM-ESMRMB, Milan, Italy, 10-16 May 2014
Year:
2014
Keywords:
Laboratories:




 Record created 2014-11-18, last modified 2018-09-13


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