Repository logo

Infoscience

  • English
  • French
Log In
Logo EPFL, École polytechnique fédérale de Lausanne

Infoscience

  • English
  • French
Log In
  1. Home
  2. Academic and Research Output
  3. Journal articles
  4. Widespread Signals of Convergent Adaptation to High Altitude in Asia and America
 
research article

Widespread Signals of Convergent Adaptation to High Altitude in Asia and America

Foll, Matthieu
•
Gaggiotti, Oscar E.
•
Daub, Josephine T.
Show more
2014
American Journal Of Human Genetics

Living at high altitude is one of the most difficult challenges that humans had to cope with during their evolution. Whereas several genomic studies have revealed some of the genetic bases of adaptations in Tibetan, Andean, and Ethiopian populations, relatively little evidence of convergent evolution to altitude in different continents has accumulated. This lack of evidence can be due to truly different evolutionary responses, but it can also be due to the low power of former studies that have mainly focused on populations from a single geographical region or performed separate analyses on multiple pairs of populations to avoid problems linked to shared histories between some populations. We introduce here a hierarchical Bayesian method to detect local adaptation that can deal with complex demographic histories. Our method can identify selection occurring at different scales, as well as convergent adaptation in different regions. We apply our approach to the analysis of a large SNP data set from low- and high-altitude human populations from America and Asia. The simultaneous analysis of these two geographic areas allows us to identify several candidate genome regions for altitudinal selection, and we show that convergent evolution among continents has been quite common. In addition to identifying several genes and biological processes involved in high-altitude adaptation, we identify two specific biological pathways that could have evolved in both continents to counter toxic effects induced by hypoxia.

  • Details
  • Metrics
Type
research article
DOI
10.1016/j.ajhg.2014.09.002
Web of Science ID

WOS:000342654300005

Author(s)
Foll, Matthieu
Gaggiotti, Oscar E.
Daub, Josephine T.
Vatsiou, Alexandra
Excoffier, Laurent
Date Issued

2014

Publisher

Cell Press

Published in
American Journal Of Human Genetics
Volume

95

Issue

4

Start page

394

End page

407

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
IBI  
Available on Infoscience
November 13, 2014
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/108671
Logo EPFL, École polytechnique fédérale de Lausanne
  • Contact
  • infoscience@epfl.ch

  • Follow us on Facebook
  • Follow us on Instagram
  • Follow us on LinkedIn
  • Follow us on X
  • Follow us on Youtube
AccessibilityLegal noticePrivacy policyCookie settingsEnd User AgreementGet helpFeedback

Infoscience is a service managed and provided by the Library and IT Services of EPFL. © EPFL, tous droits réservés