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conference paper

On the DCJ Median Problem

Shao, Mingfu  
•
Moret, Bernard M. E.  
Kulikov, As
•
Kuznetsov, So
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2014
Combinatorial Pattern Matching, Cpm 2014
25th Annual Symposium on Combinatorial Pattern Matching (CPM)

As many whole genomes are sequenced, comparative genomics is moving from pairwise comparisons to multiway comparisons framed within a phylogenetic tree. A central problem in this process is the inference of data for internal nodes of the tree from data given at the leaves. When phrased as an optimization problem, this problem reduces to computing a median of three genomes under the operations (evolutionary changes) of interest. We focus on the universal rearrangement operation known as double-cut-and join (DCJ) and present three contributions to the DCJ median problem. First, we describe a new strategy to find so-called adequate subgraphs in the multiple breakpoint graph, using a seed genome. We show how to compute adequate subgraphs w.r.t. this seed genome using a network flow formulation. Second, we prove that the upper bound of the median distance computed from the triangle inequality is tight. Finally, we study the question of whether the median distance can reach its lower and upper bounds. We derive a necessary and sufficient condition for the median distance to reach its lower bound and a necessary condition for it to reach its upper bound and design algorithms to test for these conditions.

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Type
conference paper
DOI
10.1007/978-3-319-07566-2_28
Web of Science ID

WOS:000342682800028

Author(s)
Shao, Mingfu  
Moret, Bernard M. E.  
Editors
Kulikov, As
•
Kuznetsov, So
•
Pevzner, P
Date Issued

2014

Publisher

Springer-Verlag Berlin

Publisher place

Berlin

Published in
Combinatorial Pattern Matching, Cpm 2014
ISBN of the book

978-3-319-07566-2

978-3-319-07565-5

Total of pages

10

Series title/Series vol.

Lecture Notes in Computer Science; 8486

Start page

273

End page

282

Subjects

genomic rearrangement

•

network flow

•

dynamic programming

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LCBB  
Event nameEvent placeEvent date
25th Annual Symposium on Combinatorial Pattern Matching (CPM)

Moscow, RUSSIA

JUN 16-18, 2014

Available on Infoscience
November 13, 2014
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/108638
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