Synthesis and structural elucidation of bioactive triorganotin (IV) derivatives of sodium deoxycholate

Trimethyl (1), tributyl (2), and triphenyl tin (3) derivatives of sodium (R)-4-((3R, 5R, 8R, 9S, 10S, 12S, 13R, 14S, 17R)-3,12-dihydroxy-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a] phenanthren-17-yl)pentanoate (sodium deoxycholate) were synthesized by refluxing sodium deoxycholate with the corresponding triorganotin(IV) chloride in 1 : 1M ratio. All the three compounds were characterized by elemental analysis, infrared spectroscopy, H-1, C-13, Sn-119 NMR, and X-ray diffraction studies. From FT-IR spectra,Delta nu values proposed bridging or chelating behavior of the ligand. The three compounds gave a trigonal bipyramidal geometry in the solid state and tetrahedral geometry in solution. Single crystal of 1 showed polymeric trigonal bipyramidal geometry. Synthesized compounds obtained were screened for their antimicrobial and antitumor activities against A2780 cell line. Results revealed that only 2 showed significant antibacterial activity. However, all the three compounds exhibited promising antifungal and anticancer activities.


Published in:
Journal Of Coordination Chemistry, 67, 10, 1851-1861
Year:
2014
Publisher:
Abingdon, Taylor & Francis Ltd
ISSN:
0095-8972
Keywords:
Laboratories:




 Record created 2014-10-23, last modified 2018-03-17


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