Glucose-Sensitive QCM-Sensors Via Direct Surface RAFT Polymerization

Thin, phenylboronic acid-containing polymer coatings are potentially attractive sensory layers for a range of glucose monitoring systems. This contribution presents the synthesis and properties of glucose-sensitive polymer brushes obtained via surface RAFT polymerization of 3-methacrylamido phenylboronic acid (MAPBA). This synthetic strategy is attractive since it allows the controlled growth of PMAPBA brushes with film thicknesses of up to 20 nm via direct polymerization of MAPBA without the need for additional post-polymerization modification or deprotection steps. QCM-D sensor chips modified with a PMAPBA layer respond with a linear change in the shift of the fundamental resonance frequency over a range of physiologically relevant glucose concentrations and are insensitive toward the presence of fructose, thus validating the potential of these polymer brush films as glucose sensory thin coatings.


Published in:
Macromolecular Rapid Communications, 35, 16, 1402-1407
Year:
2014
Publisher:
Weinheim, Wiley-Blackwell
ISSN:
1022-1336
Keywords:
Laboratories:




 Record created 2014-10-23, last modified 2018-09-13


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