The OPEP protein model: from single molecules, amyloid formation, crowding and hydrodynamics to DNA/RNA systems

The OPEP coarse-grained protein model has been applied to a wide range of applications since its first release 15 years ago. The model, which combines energetic and structural accuracy and chemical specificity, allows the study of single protein properties, DNA-RNA complexes, amyloid fibril formation and protein suspensions in a crowded environment. Here we first review the current state of the model and the most exciting applications using advanced conformational sampling methods. We then present the current limitations and a perspective on the ongoing developments.


Published in:
Chemical Society Reviews, 43, 13, 4871-4893
Year:
2014
Publisher:
Cambridge, Royal Society of Chemistry
ISSN:
0306-0012
Laboratories:




 Record created 2014-08-29, last modified 2018-03-17


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