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  4. Arginine-Based Biodegradable Ether–Ester Polymers with Low Cytotoxicity as Potential Gene Carriers
 
research article

Arginine-Based Biodegradable Ether–Ester Polymers with Low Cytotoxicity as Potential Gene Carriers

Memanishvili, Tamar
•
Zavradashvili, Nino
•
Kupatadze, Nino
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2014
Biomacromolecules

The success of gene therapy depends on safe and effective gene carriers. Despite being widely used, synthetic vectors based on poly(ethylenimine) (PEI), poly(l-lysine) (PLL), or poly(l-arginine) (poly-Arg) are not yet fully satisfactory. Thus, both improvement of established carriers and creation of new synthetic vectors are necessary. A series of biodegradable arginine-based ether–ester polycations was developed, which consists of three main classes: amides, urethanes, and ureas. Compared to that of PEI, PLL, and poly-Arg, much lower cytotoxicity was achieved for the new cationic arginine-based ether–ester polymers. Even at polycation concentrations up to 2 mg/mL, no significant negative effect on cell viability was observed upon exposure of several cell lines (murine mammary carcinoma, human cervical adenocarcinoma, murine melanoma, and mouse fibroblast) to the new polymers. Interaction with plasmid DNA yielded compact and stable complexes. The results demonstrate the potential of arginine-based ether–ester polycations as nonviral carriers for gene therapy applications.

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Type
research article
DOI
10.1021/bm5005977
Web of Science ID

WOS:000340348600003

Author(s)
Memanishvili, Tamar
Zavradashvili, Nino
Kupatadze, Nino
Tugushi, David
Gverdtsiteli, Marekh
Torchilin, Vladimir P.
Wandrey, Christine
Baldi, Lucia  
Manoli, Sagar S.
Katsarava, Ramaz
Date Issued

2014

Publisher

Amer Chemical Soc

Published in
Biomacromolecules
Article Number

140711090449007

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
IBI  
Available on Infoscience
July 14, 2014
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/105038
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