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  4. Robust T1-Weighted Structural Brain Imaging and Morphometry at 7T Using MP2RAGE
 
research article

Robust T1-Weighted Structural Brain Imaging and Morphometry at 7T Using MP2RAGE

O'Brien, Kieran R.  
•
Kober, Tobias  
•
Hagmann, Patric
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2014
PloS One

Purpose To suppress the noise, by sacrificing some of the signal homogeneity for numerical stability, in uniform T1 weighted (T1w) images obtained with the magnetization prepared 2 rapid gradient echoes sequence (MP2RAGE) and to compare the clinical utility of these robust T1w images against the uniform T1w images. Materials and Methods 8 healthy subjects (29.0±4.1 years; 6 Male), who provided written consent, underwent two scan sessions within a 24 hour period on a 7T head-only scanner. The uniform and robust T1w image volumes were calculated inline on the scanner. Two experienced radiologists qualitatively rated the images for: general image quality; 7T specific artefacts; and, local structure definition. Voxel-based and volume-based morphometry packages were used to compare the segmentation quality between the uniform and robust images. Statistical differences were evaluated by using a positive sided Wilcoxon rank test. Results The robust image suppresses background noise inside and outside the skull. The inhomogeneity introduced was ranked as mild. The robust image was significantly ranked higher than the uniform image for both observers (observer 1/2, p-value = 0.0006/0.0004). In particular, an improved delineation of the pituitary gland, cerebellar lobes was observed in the robust versus uniform T1w image. The reproducibility of the segmentation results between repeat scans improved (p-value = 0.0004) from an average volumetric difference across structures of ≈6.6% to ≈2.4% for the uniform image and robust T1w image respectively. Conclusions The robust T1w image enables MP2RAGE to produce, clinically familiar T1w images, in addition to T1 maps, which can be readily used in uniform morphometry packages.

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Type
research article
DOI
10.1371/journal.pone.0099676
Author(s)
O'Brien, Kieran R.  
Kober, Tobias  
Hagmann, Patric
Maeder, Philippe
Marques, José
Lazeyras, Francois
Krueger, Gunnar  
Roche, Alexis  
Date Issued

2014

Publisher

Public Library of Science

Published in
PloS One
Volume

9

Issue

6

Article Number

e99676

Subjects

CIBM-AIT

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
CIBM  
Available on Infoscience
June 21, 2014
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/104550
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