PDMS Microchannel Regenerative Peripheral Nerve Interface

We have fabricated a soft silicone structure to support the regeneration of a sciatic nerve. The device consists of 70 parallel (120 x 110 mu m(2)) channels through which axons extend and then reconnect to the muscles on the other side of the device. Through histology and electrophysiology, we show that axons grow through the device and functionality of the muscle control is restored. Nerve functionality as demonstrated with stimulated electromyography (EMG) recordings is still intact at 9 months after implantation. Future work on this device will include electrodes for recording and stimulating the regenerating nerve.


Published in:
2013 6Th International Ieee/Embs Conference On Neural Engineering (Ner), 649-652
Presented at:
6th International IEEE EMBS Conference on Neural Engineering (NER)
Year:
2013
Publisher:
New York, Ieee
ISSN:
1948-3546
ISBN:
978-1-4673-1969-0
Laboratories:




 Record created 2014-06-02, last modified 2018-03-17


Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)