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research article
Yeast Three-Hybrid Screening for Identifying Anti-Tuberculosis Drug Targets
2013
Mycobacterium goes yeast: Target deconvolution of anti-tuberculosis drugs can be a very challenging task. Here we report a yeast 3-hybrid system that allows promising small molecules to be screened for protein targets of a pathogen in nontoxic yeast cells. The system employs libraries of randomly fragmented bacterial DNA and offers a technically simple alternative approach for target identification. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Type
research article
Web of Science ID
WOS:000330181300002
Authors
Publication date
2013
Publisher
Published in
Volume
14
Issue
17
Start page
2239
End page
2242
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
June 2, 2014
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